Why new vaccines
The only vaccine currently available for immunization against tuberculosis (TB) infections is the so-called Bacille Calmette-Guerin (BCG). BCG is the most widely used of all childhood vaccines and has been available since the 1920s. Delivered at or near birth, it has been shown consistently to provide significant protection against severe childhood forms of disease, including the often fatal tuberculous meningitis. It also provides appreciable protection against leprosy. However, it has failed to protect consistently against the main problem of infection with Mycobacterium tuberculosis, i.e. adolescent and adult pulmonary TB in endemic countries in the South. Read more about why we need new vaccines.
TB vaccine pipeline
There has been tremendous progress in TB vaccine development over the past decade, with 15 vaccine candidates and candidate regiments in clinical trials and many others in preclinical research and earlier stages of development. View the latest report of Treatment Action Group, including the pipeline of TB vaccine candidates in clinical development. See the pipeline of TB vaccine candidates.